page 03 4. Which row in the table is correct for positive modulators? Binding site Effect of binding on enzyme affinity for substrate A allosteric increases B active increases C allosteric decreases D active decreases 5. Which row in the table describes events in signalling by the hormone insulin? Location of insulin binding site Mechanism of signal transduction A intracellular G‑protein activation B intracellular phosphorylation C extracellular G‑protein activation D extracellular phosphorylation [Turn over